About Conolidine alkaloid for chronic pain
Most not too long ago, it has been identified that conolidine and the above mentioned derivatives act on the atypical chemokine receptor three (ACKR3. Expressed in similar locations as classical opioid receptors, it binds into a wide array of endogenous opioids. Not like most opioid receptors, this receptor functions being a scavenger and won't act